Cyclic Voltammetric Investigation of Interactions between Bisnitroaromatic Compounds and ds.DNA 


Vol. 58,  No. 2, pp. 153-159, Apr.  2014
10.5012/jkcs.2014.58.2.153


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  Abstract

Herein, the cyclic voltammetric (CV) investigations of structurally similar bisnitrocompounds (N3, N4, N5, N6, having different -CH2- spacer length) is presented. CV study offered interesting interactional possibilities of bisnitrocompounds with chicken blood ds.DNA at physiological pH 4.7 and human body temperature, 310 K. The results indicated strong interaction by these symmetric molecules with ds.DNA and strength of binding is found to depend on length of CH2 spacer group in their molecular structure. Thermodynamics derived from electrochemical binding parameters also favored the irreversible interactions. Moreover, threading intercalation mode of binding is suggested based on thermodynamic and kinetic binding parameters extracted from CV studies.

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  Cite this article

[IEEE Style]

N. K. Janjua, Z. Akhter, F. Jabeen, B. Iftikhar, "Cyclic Voltammetric Investigation of Interactions between Bisnitroaromatic Compounds and ds.DNA," Journal of the Korean Chemical Society, vol. 58, no. 2, pp. 153-159, 2014. DOI: 10.5012/jkcs.2014.58.2.153.

[ACM Style]

Naveed Kausar Janjua, Zareen Akhter, Fariya Jabeen, and Bushra Iftikhar. 2014. Cyclic Voltammetric Investigation of Interactions between Bisnitroaromatic Compounds and ds.DNA. Journal of the Korean Chemical Society, 58, 2, (2014), 153-159. DOI: 10.5012/jkcs.2014.58.2.153.

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ISSN(Print) 1017-2548
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