Synthesis and Biological Activity of (2-Substituted-4-methylthiazol-5-yl) (4-substituted piperazin-1-yl)methanone Derivatives 


Vol. 58,  No. 1, pp. 62-67, Feb.  2014
10.5012/jkcs.2014.58.1.62


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  Abstract

In the present study a novel series of (2-substituted-4-methylthiazol-5-yl)(4-substituted piperazin-1-yl)methanone derivatives were synthesized by reaction of 2-substituted-4-methylthiazole-5-carboxylic acid with N-substituted benzyl piperazine by using 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide hydrochloride (EDCl) and 1-hydroxybenzotriazole (HOBt) in DMF. All the newly synthesized compounds were characterized by spectral methods. The title compounds were screened for in vitro antibacterial activity. Most of the compounds show moderate to good antimicrobial activity.

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  Cite this article

[IEEE Style]

P. C. Mhaske, S. H. Shelke, H. N. Raundal, R. P. Jadhav, "Synthesis and Biological Activity of (2-Substituted-4-methylthiazol-5-yl) (4-substituted piperazin-1-yl)methanone Derivatives," Journal of the Korean Chemical Society, vol. 58, no. 1, pp. 62-67, 2014. DOI: 10.5012/jkcs.2014.58.1.62.

[ACM Style]

Pravin C Mhaske, Shivaji H Shelke, Hemant N Raundal, and Rahul P Jadhav. 2014. Synthesis and Biological Activity of (2-Substituted-4-methylthiazol-5-yl) (4-substituted piperazin-1-yl)methanone Derivatives. Journal of the Korean Chemical Society, 58, 1, (2014), 62-67. DOI: 10.5012/jkcs.2014.58.1.62.

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ISSN(Print) 1017-2548
ISSN(Online) 2234-8530