Synthesis and Biological Activities of Novel Arylazopyrazolones Substituted with Thiazolyhydrazone 


Vol. 58,  No. 1, pp. 57-61, Feb.  2014
10.5012/jkcs.2014.58.1.57


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  Abstract

The 4-(1H)-benzotriazoyl methyl amino benzoate 3 was prepared by Mannich reaction of benzotriazole 1, ethyl-paminobenzoate 2 and formaldehyde. The prepared compound 3 then react with hydrazine hydrate results in the 4-(1H)-benzotriazoyl methyl amino benzoyl hydrazide 4. This compound on condensation with pre-prepared different ethyl 2-(2-(4-(4-substituted phenyl)thiazol-2-yl)hydrazono)-3-oxobutanoates 6a-d, furnished 1-(4-((1H-benzo[d] [1,2,3] triazol-1-yl)methyl amino) benzoyl)-4-(2-(4-(4-substituted phenyl)thiazol-2-yl) hydrazono)-3-methyl-1H-pyrazol-5(4H)-one 7a-d. All the compounds 7a-d was characterized by spectral studies. The compounds showed significant antimicrobial activity against various bacteria and fungi.

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  Cite this article

[IEEE Style]

P. J. Shah, "Synthesis and Biological Activities of Novel Arylazopyrazolones Substituted with Thiazolyhydrazone," Journal of the Korean Chemical Society, vol. 58, no. 1, pp. 57-61, 2014. DOI: 10.5012/jkcs.2014.58.1.57.

[ACM Style]

Purvesh J Shah. 2014. Synthesis and Biological Activities of Novel Arylazopyrazolones Substituted with Thiazolyhydrazone. Journal of the Korean Chemical Society, 58, 1, (2014), 57-61. DOI: 10.5012/jkcs.2014.58.1.57.

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