Synthesis, Characterization and Antimicrobial Activity of Bifunctional Sulfonamide-Amide Derivatives 


Vol. 57,  No. 6, pp. 731-737, Dec.  2013
10.5012/jkcs.2013.57.6.731


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  Abstract

A convenient synthesis of bifunctional sulfonamide-amide derivatives was reported. Amide coupling of 4-methyl benzoic acid 1 followed by reaction with chlorosulfonic acid produce ethyl-4-(3-(chlorosulfonyl)-4-methylbenzoyl)piperazine- 1-carboxylate 4. The resulted compound on further treatment with various anilines produces the title sulfonamide-amide derivatives 5a-n. The configurations of these compounds were established by elemental analysis, IR, 1H NMR, mass spectra, and by their preparation from the corresponding 4-methyl benzoic acid 1 and chlorosulfonic acid. All these new compounds demonstrate significant in vitro antibacterial and antifungal activities against all bacterial and fungal strains.

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  Cite this article

[IEEE Style]

B. R. A. Abbavaram and H. R. V. Reddyvari, "Synthesis, Characterization and Antimicrobial Activity of Bifunctional Sulfonamide-Amide Derivatives," Journal of the Korean Chemical Society, vol. 57, no. 6, pp. 731-737, 2013. DOI: 10.5012/jkcs.2013.57.6.731.

[ACM Style]

Babul Reddy A Abbavaram and Hymavathi R V Reddyvari. 2013. Synthesis, Characterization and Antimicrobial Activity of Bifunctional Sulfonamide-Amide Derivatives. Journal of the Korean Chemical Society, 57, 6, (2013), 731-737. DOI: 10.5012/jkcs.2013.57.6.731.

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ISSN(Print) 1017-2548
ISSN(Online) 2234-8530