Synthesis and Screening of Some Novel 2-[5-(Substituted phenyl)-[1,3,4]oxadiazol-2-yl]-benzoxazoles as Potential Antimicrobial Agents 


Vol. 57,  No. 2, pp. 221-226, Apr.  2013
10.5012/jkcs.2013.57.2.221


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  Abstract

A series of some novel 2-[5-(substituted phenyl)-[1,3,4]oxadiazol-2-yl]-benzoxazoles were synthesized by using benzoxazole-2-carboxylic acid on reaction with thionyl chloride in presence of ethanol solvent at room temperature gave benzoxazole-2-carbonyl chloride, which is turned into benzoxazole-2-carboxylic acid hydrazide on reaction with hydrazine hydrate in ethanol solvent under reflux. The subsequent treatment of benzoxazole-2-carboxylic acid hydrazide with an appropriate aromatic carboxylic acid in presence of polyphosparic acid under reflux afforded the title compounds. The chemical structures of the newly synthesized compounds were elucidated by their IR, 1H NMR and Mass spectral data analysis. Further the compounds are used to find out their ability towards anti microbial and nematicidal activity.

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  Cite this article

[IEEE Style]

H. Gadegoni, S. Manda, S. Rangu, "Synthesis and Screening of Some Novel 2-[5-(Substituted phenyl)-[1,3,4]oxadiazol-2-yl]-benzoxazoles as Potential Antimicrobial Agents," Journal of the Korean Chemical Society, vol. 57, no. 2, pp. 221-226, 2013. DOI: 10.5012/jkcs.2013.57.2.221.

[ACM Style]

Hemalatha Gadegoni, Sarangapani Manda, and Shivaprasad Rangu. 2013. Synthesis and Screening of Some Novel 2-[5-(Substituted phenyl)-[1,3,4]oxadiazol-2-yl]-benzoxazoles as Potential Antimicrobial Agents. Journal of the Korean Chemical Society, 57, 2, (2013), 221-226. DOI: 10.5012/jkcs.2013.57.2.221.

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ISSN(Print) 1017-2548
ISSN(Online) 2234-8530