DNA Binding Studies and Cytotoxicity of the Novel 1,10-phenanthroline Palladium(II) Complexes of Dithiocarbamate Derivatives 


Vol. 55,  No. 1, pp. 70-80, Feb.  2011
10.5012/jkcs.2011.55.1.070


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  Abstract

두 종류의 새로운 팔라디움(II) 착물인 [Pd(phen)(pip-dtc)]N3와 [Pd(phen)(mor-dtc)]N3 (여기서 phen은 1,10-페난 트롤린, pip-dtc은 피페리딘디티오카르바메이트 음이온, mor-dtc은 모르폴린디티오카르바메이트 음이온을 가리킨다)를 합성 하고 원소분석, 분광법(FT-IR, 1H NMR, UV-Vis) 및 전기전도도 측정을 이용하여 특성을 조사하였다. 이 착물들에서, 디티 오카르베이트 리간드는 팔라디움 (II) 중심과 두 개의 황 원자와 이중으로 배위 결합을 하고 있다. 이 착물의 세포독성을 K562 세포주를 이용하여 조사하였을 때 I50 값이 시스플라틴보다 작았기 때문에 착물들의 송아지 흉선 DNA(CT-DNA) 와의 결합 모드를 UV 흡광도 차이와 형광 분광법으로 조사하였다. 착물들은 DNA를 변형시키고, 협동결합을 하고, DNA 에 끼어 들어간다. 또한 몇 가지 결합 및 열역학적인 변수들이 기술되었다. Two new palladium (II) complexes, [Pd (phen)(pip-dtc)]N3 and [Pd(phen)(mor-dtc)]N3, (where phen is 1,10-Phenantroline, pip-dtc is piperidinedithiocarbamate anion and mor-dtc is morpholinedithiocarbamate anion) have been synthesized and characterized by elemental analysis, spectroscopic studies (FT-IR, 1 H NMR, UV-Vis) and conductance measurement. In these complexes, the dithiocarbamate ligands coordinate with Pd (II) center as bidentate with two sulfur atoms. These two complexes have been tested against chronic myelogenous leukemia cell line, K562. They show I50 values less than cisplatin and thus the mode of binding of the complexes to calf thymus DNA (CT-DNA) were investigated by ultraviolet difference and fluorescence spectroscopy. They can denature DNA, exhibit cooperative binding and intercalate into DNA. Several binding and thermodynamic parameters are also described.

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  Cite this article

[IEEE Style]

H. M. Torshizi, M. Saeidifar, Z. Y. Ghasemi, M. Khastan, A. Divsalar, A. A. Saboury, "DNA Binding Studies and Cytotoxicity of the Novel 1,10-phenanthroline Palladium(II) Complexes of Dithiocarbamate Derivatives," Journal of the Korean Chemical Society, vol. 55, no. 1, pp. 70-80, 2011. DOI: 10.5012/jkcs.2011.55.1.070.

[ACM Style]

Hassan Mansouri Torshizi, Maryam Saeidifar, Zahra Yekke Ghasemi, Mahmood Khastan, Adeleh Divsalar, and Ali Akbar Saboury. 2011. DNA Binding Studies and Cytotoxicity of the Novel 1,10-phenanthroline Palladium(II) Complexes of Dithiocarbamate Derivatives. Journal of the Korean Chemical Society, 55, 1, (2011), 70-80. DOI: 10.5012/jkcs.2011.55.1.070.

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ISSN(Print) 1017-2548
ISSN(Online) 2234-8530