Improvement of the Synthetic Route for Epinastine Antihistamine 


Vol. 54,  No. 4, pp. 447-450, Aug.  2010
10.5012/jkcs.2010.54.4.447


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  Abstract

In this study, the improved large-scale synthetic route for epinastine hydrochloride, the second-generation antihistamine, was developed. The original synthetic route involves the synthesis of an aminomethyl derivative, the main intermediate, and in this process hazardous materials such as very toxic phosgene and sodium cyanide along with the explosive and expensive aluminum chloride and lithium aluminum hydride were used. In order to improve the synthetic route, we developed industrially very useful process to prepare the aminomethyl intermediate by the synthesis of the phthalimidomethyl derivative first and easy removal of the phthalyl group using hydrochloric acid or methyl hydrazine, and hazardous materials and expensive reagents were excluded in this process.

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  Cite this article

[IEEE Style]

D. J. Baek and M. S. Kim, "Improvement of the Synthetic Route for Epinastine Antihistamine," Journal of the Korean Chemical Society, vol. 54, no. 4, pp. 447-450, 2010. DOI: 10.5012/jkcs.2010.54.4.447.

[ACM Style]

Du Jong Baek and Moon Sik Kim. 2010. Improvement of the Synthetic Route for Epinastine Antihistamine. Journal of the Korean Chemical Society, 54, 4, (2010), 447-450. DOI: 10.5012/jkcs.2010.54.4.447.

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ISSN(Print) 1017-2548
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