Microwave Irradiation and Diisopropylcarbodiimide (DIC)/7-Aza-1-hydroxybenzotriazole (HOAt): A Potent Combination for Synthesis of Variuos Hydrazide from N-Protected Amino Acid and Hydrazine 


Vol. 54,  No. 4, pp. 419-428, Aug.  2010
10.5012/jkcs.2010.54.4.419


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  Abstract

Here we describe a fast and rapid technique for preparation of amino acid hydrazide as well as peptide hydrazide derivatives using diisopropylcarbodiimide (DIC)/1-hydroxybenzotriazoles (HOXt) (X = A or B) under microwave irradiation employing a multimode reactor (Synthos 3000 Aton Paar, GmbH, 1400 W maximum magnetron). A comparison between conventional and microwave irradiation was described. The microwave methodology is rapid, convenient, proceeds under mild conditions. Diisopropylcarbodiimide (DIC)/7-aza-1-hydroxybenzotriazole (HOAt) always gave much better yield (95 - 98%) and purity than diisopropylcarbodiimide (DIC)/1-hydroxybenzotriazole (HOBt).

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  Cite this article

[IEEE Style]

M. Albatal, M. A. Ghani, A. E. Faham, H. M. A. Hazimi, H. H. Hammud, "Microwave Irradiation and Diisopropylcarbodiimide (DIC)/7-Aza-1-hydroxybenzotriazole (HOAt): A Potent Combination for Synthesis of Variuos Hydrazide from N-Protected Amino Acid and Hydrazine," Journal of the Korean Chemical Society, vol. 54, no. 4, pp. 419-428, 2010. DOI: 10.5012/jkcs.2010.54.4.419.

[ACM Style]

Mona Albatal, Mohamad Abdul Ghani, Ayman El Faham, Hassan M Al Hazimi, and Hassan H Hammud. 2010. Microwave Irradiation and Diisopropylcarbodiimide (DIC)/7-Aza-1-hydroxybenzotriazole (HOAt): A Potent Combination for Synthesis of Variuos Hydrazide from N-Protected Amino Acid and Hydrazine. Journal of the Korean Chemical Society, 54, 4, (2010), 419-428. DOI: 10.5012/jkcs.2010.54.4.419.

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ISSN(Print) 1017-2548
ISSN(Online) 2234-8530