Unusual Formation of N-hydroxy-3,3-dimethyl-2,6-diarylpiperidin-4-one and its Thiosemicarbazide Derivative-Synthesis and Antimicrobial Activity 


Vol. 52,  No. 5, pp. 503-510, Oct.  2008
10.5012/jkcs.2008.52.5.503


PDF
  Abstract

다수의 새로운 N-Hydroxy-3,3-dimethyl-2,6-diarylpiperidin-4-one thiosemicarbazones들을 합성하였고 녹 는점, 원소 분석, MS, FT-IR, NMR (1H & 13C) 데이터로 구조분석 하였으며, in vitro 항균성과 항진균성의 활성을 측정하였다. 합성되어진 모든 화합물중에서, 화합물 31 은 대장균을 제외한 전체 시험되어진 gram-양성, gram-음성 박 테리아들에 대해 광범위한 항균 활성을 보여주고 있다. 화합물 31은 Aspergillus flavus, 털곰팡이, Microsporum gypsuem에 강한 항진균성을 보였다. An array of novel N-Hydroxy-3,3-dimethyl-2,6-diarylpiperidin-4-one thiosemicarbazones 28-32 are synthesized, characterized by melting point, elemental analysis, MS, FT-IR, NMR (1H & 13C) spectroscopic data and evaluated for their in vitro antibacterial and antifungal activities. Of all the compounds synthesized, compound 31, exerted a wide range of antibacterial activities against the entire tested gram-positive and gram-negative bacterial strains except Escherichia coli. Compound 31 exerted strong antifungal activities against Aspergillus flavus, Mucor and Microsporum gypsuem.

  Statistics
Cumulative Counts from November, 2022
Multiple requests among the same browser session are counted as one view. If you mouse over a chart, the values of data points will be shown.


  Cite this article

[IEEE Style]

M. Gopalakrishnan, P. Sureshkumar, J. Thanusu, V. Kanagarajan, "Unusual Formation of N-hydroxy-3,3-dimethyl-2,6-diarylpiperidin-4-one and its Thiosemicarbazide Derivative-Synthesis and Antimicrobial Activity," Journal of the Korean Chemical Society, vol. 52, no. 5, pp. 503-510, 2008. DOI: 10.5012/jkcs.2008.52.5.503.

[ACM Style]

M. Gopalakrishnan, P. Sureshkumar, J. Thanusu, and V. Kanagarajan. 2008. Unusual Formation of N-hydroxy-3,3-dimethyl-2,6-diarylpiperidin-4-one and its Thiosemicarbazide Derivative-Synthesis and Antimicrobial Activity. Journal of the Korean Chemical Society, 52, 5, (2008), 503-510. DOI: 10.5012/jkcs.2008.52.5.503.

Search
(IN TITLE, AUTHOR, ABSTRACT,KEYWORDS)

Advanced Search ▼

POPULAR KEYWORDS
(TOP 10 KEYWORDS)

Recent Publications
(LAST 3 YEARS)

ISSN(Print) 1017-2548
ISSN(Online) 2234-8530