The Study of Doxorubicin and its Interaction with Adenine by UV-Resonance Raman Spectroscopy 


Vol. 52,  No. 2, pp. 118-123, Apr.  2008
10.5012/jkcs.2008.52.2.118


PDF
  Abstract

항암제인 독소루비신과 아데닌과의 상호작용을 알아보기 위하여 10-3~10-4의 수용액상 농도 범위에 서 1 : 2의 부피비로 혼합하여 조사하였다. 자외선 공명라만 분광법과 표면증강 라만 분광법을 이용하여 수용 액상에서 독소루비신 분자의 아데닌 분자에 대한 결합 자리를 알아 본 결과 독소루비신 분자는 아데닌 분자 의 7번 위치의 질소와 상호작용 가능성을 확인할 수 있었다. The interaction of the antitumour agent, doxorubicin, with adenine is investigated in an aqueous solution at a concentration of 10-3~10-4 with volume ratios of 1:2. A UV-resonance Raman spectroscopy and surface enhanced Raman spectroscopy are used to determine the binding sites of doxorubicin to adenine and the structural variations of doxorubicin-adenine complexes in an aqueous solution. We identified that the possibilities of doxorubicin interacted with the N7 positions of adenine.

  Statistics
Cumulative Counts from November, 2022
Multiple requests among the same browser session are counted as one view. If you mouse over a chart, the values of data points will be shown.


  Cite this article

[IEEE Style]

C. Lee and M. Jung, "The Study of Doxorubicin and its Interaction with Adenine by UV-Resonance Raman Spectroscopy," Journal of the Korean Chemical Society, vol. 52, no. 2, pp. 118-123, 2008. DOI: 10.5012/jkcs.2008.52.2.118.

[ACM Style]

Chul-Jae Lee and Maeng-Joon Jung. 2008. The Study of Doxorubicin and its Interaction with Adenine by UV-Resonance Raman Spectroscopy. Journal of the Korean Chemical Society, 52, 2, (2008), 118-123. DOI: 10.5012/jkcs.2008.52.2.118.

Search
(IN TITLE, AUTHOR, ABSTRACT,KEYWORDS)

Advanced Search ▼

POPULAR KEYWORDS
(TOP 10 KEYWORDS)

Recent Publications
(LAST 3 YEARS)

ISSN(Print) 1017-2548
ISSN(Online) 2234-8530