Synthesis of Poly(DL-lactide-co-glycolide) Copolymers and Its Application(I). Release Characteristics of Clonazepam Using Poly(DL-lactide-co-glycolide)(80:20) Copolymers 


Vol. 42,  No. 1, pp. 92-98, Feb.  1998


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  Abstract

DL-lactide와 glycolide로부터 공중합체 Poly(DL-lactide-co-glycolide) (80:20)를 합성하였다. 합성된 공중합체에 소수성 약물인 clonazepam을 함유하는 미소구체를 제조하여 약물전달시스템 제제로서 응용 가능성을 고찰하였다. 미소구체로부터 약물방출실험은 pH 7.4 phosphate buffer solution 37.0±0.05 ℃에서 시행하였다. 미소구체로부터 약물인 선형적으로 방출된 시간범위는 고분자와 약물의 무게비가 20:40(mg) 인 경우는 51일 이었고, 20:20과 40:20 (mg)의 비율의 경우는 각각 41일, 29일로 미소구체 제조시 약물의 비율이 증가함에 따라 방출시간 또한 길어짐을 알 수 있다. 결론적으로 본 실험의 diafiltration법에 의해 균일한 크기의 미소구체를 제조할 수 있었으며, 약물은 조절 방출형 pattern을 보여 약물전달시스템 제제로서 응용 가능성을 알 수 있었다. Poly(DL-lactide-co-glycolide) (80:20) was synthesized from DL-lactide and glycolide, and the copolymers was made to micelles containing clonazepam for drug delivery system. The release experiments of the drug from micelles were operated at pH 7.4 phosphate buffer solution 37.0±0.05 ℃. The linearly-releasing time ranges of the drug from micelles prepared with the copolymer/drug weight ratio of 20:40, 20:20, and 40:20 (mg) were 50, 41, and 20 days, respectively. So the linearly-releasing time of drug showed the order of micelles 20/40 > micelles 20/20 > micelles 40/20. In short, the formulation allows polymeric micelles to suppress the burst effect of the drug release mechanism, which led to the controlled release pattern and the possibility of drug delivery system for veinous injection.

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  Cite this article

[IEEE Style]

J. Nah, D. Lee, C. Cho, Y. Jeong, S. Kim, S. Kim, "Synthesis of Poly(DL-lactide-co-glycolide) Copolymers and Its Application(I). Release Characteristics of Clonazepam Using Poly(DL-lactide-co-glycolide)(80:20) Copolymers," Journal of the Korean Chemical Society, vol. 42, no. 1, pp. 92-98, 1998. DOI: .

[ACM Style]

Jae-Woon Nah, Dong-Byung Lee, Chong-Su Cho, Young-Il Jeong, Sung-Ho Kim, and Sung-Hyun Kim. 1998. Synthesis of Poly(DL-lactide-co-glycolide) Copolymers and Its Application(I). Release Characteristics of Clonazepam Using Poly(DL-lactide-co-glycolide)(80:20) Copolymers. Journal of the Korean Chemical Society, 42, 1, (1998), 92-98. DOI: .

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