Structure-Activity Relationship (Ⅱ). Structure and Activity of Folate Analogues 


Vol. 37,  No. 4, pp. 448-452, Aug.  1993


PDF
  Abstract

Folate 유사체의 anti-folate 활성과 물리적 성질의 상관성을 찾기 위하여 기하구조 파라미터, 쌍극자 모멘트, net charg, HOMO, LUMO 에너지 등 전자의 구조적 특성을 MM2와 MOT에 의해 검토하였다. 전자적 성질은 folate 유사체의 inhibition과 어떠한 상관성도 보이지 않았으며 형태분석에 의한 기하구조 파라미터가 상관성을 나타내었다. To find out a correlation between anti-folate activity and physical properties of folate analogues, geometric parameters, dipole moment, net charges, HOMO and LUMO energies were calculated. The electronic properties do not give any correlations with inhibition of folate reductase, but the calculated geometries show some correlations.

  Statistics
Cumulative Counts from November, 2022
Multiple requests among the same browser session are counted as one view. If you mouse over a chart, the values of data points will be shown.


  Cite this article

[IEEE Style]

S. Park and S. Yoh, "Structure-Activity Relationship (Ⅱ). Structure and Activity of Folate Analogues," Journal of the Korean Chemical Society, vol. 37, no. 4, pp. 448-452, 1993. DOI: .

[ACM Style]

Seongsik Park and Soo-Dong Yoh. 1993. Structure-Activity Relationship (Ⅱ). Structure and Activity of Folate Analogues. Journal of the Korean Chemical Society, 37, 4, (1993), 448-452. DOI: .

Search
(IN TITLE, AUTHOR, ABSTRACT,KEYWORDS)

Advanced Search ▼

POPULAR KEYWORDS
(TOP 10 KEYWORDS)

Recent Publications
(LAST 3 YEARS)

ISSN(Print) 1017-2548
ISSN(Online) 2234-8530